Simian immunodeficiency virus infection in free-ranging sooty Mangabeys (Cercocebus atys atys) from the Tai Forest, Cote d'Ivoire

Simian Immunodeficiency Virus Infection in Free-Ranging Sooty Mangabeys (Cercocebus atys atys) from the Taı̈ Forest, Côte d’Ivoire: Implications for the Origin of Epidemic Human Immunodeficiency Virus Type 2

Mario L. Santiago,† Friederike Range,‡ Brandon F. Keele, Yingying Li, Elizabeth Bailes, Frederic Bibollet-Ruche, Cecile Fruteau, Ronald Noë, Martine Peeters, John F. Y. Brookfield, George M. Shaw, Paul M. Sharp, and Beatrice H. Hahn* Departments of Medicine and Microbiology, University of Alabama at Birmingham, and Howard Hughes Medical Institute, Birmingham, Alabama 35294; Department of Psycho...

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus

The C-C chemokine receptor CCR5 in humans and rhesus macaques (Macaca mulatta) serves as the primary coreceptor for cellular entry by macrophagetropic strains of human immunodeficiency virus type 1 (HIV-1) and all reported strains of simian immunodeficiency virus (SIV) [1-6]. Humans homozygous for a 32 bp deletion allele of CCR5, resulting in a null phenotype, are highly resistant to infection ...

SIV from Lymph Nodes of Sooty Mangabeys Lymphocytes and Rapid Disappearance of Immunodeficiency Virus (SIV)-Specific T Early Induction of Polyfunctional Simian

The paradox of simian immunodeficiency virus infection in sooty mangabeys: active viral replication without disease progression.

Simian immunodeficiency virus SIVsm causes an asymptomatic infection in its natural host, the sooty mangabey, but induces an immunodeficiency syndrome very similar to human AIDS when transferred to a new host species such as the rhesus macaque. Unexpectedly, SIVsm replication dynamics is comparable in the two species, with rapid accumulation of viral mutations and a high viral load detected in ...

AIDS as a zoonosis: scientific and public health implications.

Evidence of simian immunodeficiency virus (SIV) infection has been reported for 26 different species of African nonhuman primates. Two of these viruses, SIVcpz from chimpanzees and SIVsm from sooty mangabeys, are the cause of acquired immunodeficiency syndrome (AIDS) in humans. Together, they have been transmitted to humans on at least seven occasions. The implications of human infection by a d...